希望对你有用。
替代传统的骨移植是必要的。Using a degradable polymer/ceramic composite system, our使用可降解聚合物/陶瓷复合系统,我们的
laboratory has developed porous matrices for use as实验室开发了多孔矩阵用作
trabecular bone graft replacements.松质骨移植替代品。 Composed of 50:50组成50:50
poly(lactide-co-glycolide) (PLAGA) and hydroxyapatite聚(乳酸共同乙醇酸) ( PLAGA )和羟基磷灰石
(HA), these matrices possess a three-dimensional (3D), porous (医管局) ,这些矩阵具有三维(三维) ,多孔
structure based on microsphere technology.结构的微球技术。 Our我们的
current studies examine the relationship between processing目前的研究审查之间的关系处理
conditions and internal matrix structure.条件和内部矩阵结构。 This has led这已导致
to the development of three novel processes capable of发展的三个新工艺能力
fabricating a 3D porous structure: (1) a sintered microsphere编造三维多孔结构: ( 1 )烧结微球
method, (2) a solvent cast microsphere method, and (3) a方法, ( 2 )溶剂铸球的方法,和( 3 )
gel microsphere method.凝胶微球的方法。
Preliminary characterization of matrix structure was初步表征矩阵结构
carried out by scanning electron microscopy (SEM).进行扫描电子显微镜( SEM ) 。 The那个
solvent cast and sintered microsphere methods used prefabricated溶剂演员和烧结微球方法预制
microspheres isolated through a solvent微分离通过溶剂
evaporation technique.蒸发技术。 SEM characterization of the sintered扫描电镜表征烧结
and solvent cast methods indicated a 3D network of铸造方法和溶剂显示三维网络
fused microspheres with a range in pore diameter from 100-融合了微球的孔径范围从100 -
450 μm and 50-250 μm, respectively. 450 μm和50-250微米分别。 The gel microsphere凝胶微球
method also used microspheres from the solvent方法也被用来从溶剂微球
evaporation technique, however, matrices were created from蒸发技术,然而,建立了由矩阵
microspheres isolated before complete solvent removal.微分离溶剂前完成搬迁。
SEM characterization indicated a 3D internal porous network扫描电镜表征表明,内部多孔三维网络
ranging in size from 100-300 μm.范围的大小从100-300微米。 It was determined that the这是确定的
porous structure was due to the aggregation of “gel-like”多孔结构是由于聚集的“凝胶样”
microspheres.微球。
Key Words: Tissue engineering, biomaterials, polymer,关键词:组织工程,生物材料,高分子,
composite, poly(lactide-co-glycolide), pore network.复合材料,聚(乳酸共同乙醇酸) ,孔网。
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